hTF/MC-38
CBPG0107
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产品描述
产品数据库
| I. Background | |
| 凝血因子 III (Coagulation Factor III)，又称组织因子(Tissue Factor，TF)或 CD142，是外 在凝血途径的主要调节因子。它缺乏内在的蛋白水解活性，但可以以 Ca 2+依赖的方式结合 活化因子 VII（FVII）或活化因子 VIIa（FVIIa），并顺利获得变构增强该蛋白酶的酶活性，催 化因子 X (FX)活化为 FXa。由于其凝血特性，TF 在血栓形成或弥散性血管内凝血等病理条 件下都具有重要作用。在动脉粥样硬化过程中，TF 大量表达，并且能够促进血栓形成。除 了发挥凝血作用外，TF 在炎症、血管生成以及肿瘤生长和转移中也具有一定作用。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hTF |
| Stability: | 32 passages |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+5μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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Figure 1. Recombinant hTF/MC-38 stably expressing TF. |
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| V. In VIVO Data | |
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Index |
Content |
|
Animal |
C57BL/6J, 6weeks, female |
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Implanted Position |
Subcutaneous (right lower flank region ) |
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Injected Cell Numbers |
1×10^6/0.1ml |
|
Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hTF/MC38 Mean Body Weight ± SEM.
2. Tumor Size
Figure 3.hTF/MC38 Mean Tumor Volume ± SEM .
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
